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July 30, 2010

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Vol. 3, No. 21, 24 October 2003

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AIDScience Report:
Calculating the potential epidemic-level impact of therapeutic vaccination on the San Francisco HIV epidemic
This model suggests that modestly effective HIV therapeutic vaccines used in combination with antiretrovirals could potentially, under defined conditions, have a fairly significant impact on the epidemic.

— By Sally M. Blower, Ronald B. Moss, Eduardo Fernandez-Cruz.

Hot News:
Use of dried whole blood spots to measure CD4+ lymphocyte counts in HIV-1-infected patients
Whole blood spots dried on filter paper were used to measure CD4+ lymphocyte counts. Measurements compared well with those obtained from matched liquid whole-blood samples analyzed with standard flow cytometry, with flow cytometry CD4 counts greater than 200 cells/µL. Lancet 362, 1459 (2003).

NeuroAIDS: Prediction of incident neurocognitive impairment by plasma HIV RNA and CD4 levels early after HIV seroconversion
High HIV plasma RNA levels and low CD4+ T cell counts soon after seroconversion are associated with a higher risk of neuropsychological impairment. Archives of Neurology 60, 1406, October 2003.

Latest News Headlines [What is this?]
	A battle line in Botswana AIDS fight
	VaxGen may restate two years of results
	E.U. warns on triple-drug HIV treatment
	China wakes up to AIDS crisis
	Clinton announces deal on AIDS drugs
	HIV, TB concern European health officials
	Still time to avert HIV crisis, experts say
	AEGiS founder advocates open access to scientific papers
	AIDS drug prices cut further
	U.S. HHS awards $156.5 million for substance abuse prevention for people with HIV
	South Africa: Controversy over new AIDS projections
	Viewpoint: Burma's long haul against AIDS
	AIDS researchers deplore lack of funding in Germany
	Fears grow that AIDS could spin out of control in India
	South Africa HIV rate 'falling'
	Vertex, Glaxo win U.S. OK for HIV drug
	U.N. AIDS fund gives China $21 Million, maybe more
	U.S. health chief warns of spread of AIDS in China, India
	U.S. prescription drug system under attack
	Glaxo in dock over AIDS drugs
	South Africa revives patent drugs issue
	Honduras has highest HIV-infection rate in Central America
	U.S. researchers identify HIV-friendly proteins
	HIV drugs boost 10-year survival
	World group backs earlier AIDS funding date
	Global Fund slows aid going to fight 3 diseases
	Viral growth in antiviral drugs
	WFP becomes ninth cosponsor of UNAIDS
	Britain: HIV conviction is a landmark case
	Researcher: South Africans must be encouraged to take HIV tests
	HIV-modified brain protein may cause HIV-associated dementia
	World Bank: Central America must invest more in prevention
	At last, Russia faces AIDS
	AIDS fighters: CDC helps China curb spread of deadly disease
	U.S. and Britain look to slow pace of spending on AIDS
	India: business urged to help AIDS battle
	Condom controversy surprises Vatican
	Donor countries not sticking to aid pledge
	Gates charity pledges $200 million to combat AIDS in India
	U.N. official: leaders must educate Asians on AIDS
	India asks AIDS drug makers to cut prices of generics
	When the drugs do work
	Bush's AIDS 'gift' has been seized by industry giants (opinion)
	Botswana: two in five
	Shifting prevention efforts to HIV carriers
	WHO rejects Vatican claims that condoms don't protect from AIDS
	AIDS patients in Zambia face stark choices
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Latest Journal Headlines [What is this?]
Vaccines:
	Long-term specific immune responses induced in humans by a HIV-1 lipopeptide vaccine. Journal of Virology.
	Microarray profiling of antibody responses against simian-human immunodeficiency virus. Journal of Virology.
	Functional HIV-1 Gag-Pol or HIV-1 Gag-Pol and Env expressed from a rhabdovirus-based vaccine vector. Journal of Virology.
	Enhancement of gp120-specific immune responses by genetic vaccination. Journal of Virology.
	Oral vaccination of mice with adenoviral vectors Is not impaired by preexisting immunity. Journal of Virology.
	AIDS vaccination studies using an ex vivo feline immunodeficiency virus model. Journal of Virology.
	Sequence conservation and antibody cross-recognition of clade B HIV-1 Tat protein. Journal of Infectious Diseases.
Prevention:
	Characteristics of individuals with male-to-male and heterosexually acquired infectious syphilis. Sexually Transmitted Diseases.
	Sexual transmission of HIV in Africa. Nature.
	Viral infections among HIV-infected and high-risk HIV-uninfected women. Journal of Infectious Diseases.
	Advancing HIV prevention: New strategies for a changing epidemic — United States, 2003. Morbidity and Mortality Weekly Report.
	Rapid fingerstick testing: A new era in HIV diagnostics. AIDS Clinical Care.
	HIV incidence among street youth in Montreal, Canada. AIDS.
	The contribution of steady and casual partnerships to the incidence of HIV infection. AIDS.
	Public policy regulating private and public space in gay bathhouses. Journal of Acquired Immune Deficiency Syndromes.
	Rectal use of nonoxynol-9 among men who have sex with men. AIDS.
	Risk factors for incident HIV infection among anonymous HIV testing site clients. Journal of Acquired Immune Deficiency Syndromes.
	Incubation and duration of specific symptoms at ARS as independent predictors of progression to AIDS. Journal of Acquired Immune Deficiency Syndromes.
	Voluntary HIV testing among inmates. Journal of Acquired Immune Deficiency Syndromes.
	Comparison of two strategies for administering nevirapine to prevent perinatal HIV transmission. Journal of Acquired Immune Deficiency Syndromes.
	Intensive injection cocaine use as the primary risk factor in the Vancouver HIV-1 epidemic. AIDS.
	Is breastfeeding best for HIV-positive mothers?. AIDS.
NeuroAIDS:
	Chlamydophila pneumoniae and HIV-associated dementia complex. Journal of Neuroimmunology.
	HIV-associated Guillain-Barre syndrome. Journal of the Neurologicals Sciences.
Virology:
	B7-H1 is up-regulated in HIV infection and is a novel surrogate marker of disease progression. Blood.
	HIV-1 Tat can favor the establishment of neoplasia. Journal of Biological Chemistry.
	Inhibition of human immunodeficiency virus type 1 env-mediated fusion by DC-SIGN. Journal of Virology.
	Increased in vitro cytopathicity of R5/NSI HIV-1 correlates with a progressive course of infection. Journal of Infectious Diseases.
	Decreased stimulation of CD4+ T cell proliferation and IL-2 production by infected dendritic cells. Journal of Immunology.
	Review: AIDS pathogenesis: what have two decades of HIV research taught us?. Nature Reviews Immunology.
	Natural variation of the nef gene in human immunodeficiency virus type 2 infections in Portugal. Journal of General Virology.
	Clade B HIV-1 superinfection with wild-type virus after primary infection. AIDS.
	Serum immunoglobulin A (IgA)-mediated immunity in HIV-2 infection. Virology.
	The functional relationship between V3 loop and gp120 context with regard to HIV coreceptor usage. Virology.
	In-utero transmission of quasispecies among human immunodeficiency virus type 1 genotypes. Virology.
	Transmission of HIV-1 infection between trophoblast placental cells and T-cells. Virology.
	Heterogeneous clearance rates of long-lived lymphocytes infected with HIV. Proc. Natl. Acad. Sci. USA.
	Innate immunity in HIV infection: Effect of viremia on natural killer cell function. Journal of Infectious Diseases.
	Microanatomic relationships between CD8+ cells and HIV-1-producing cells in human lymphoid tissue. Journal of Acquired Immune Deficiency Syndromes.
	Bystander CD4(+) T lymphocytes survive in HIV-infected human lymphoid tissue. AIDS Research and Human Retroviruses.
	Enhanced transcytosis of R5 HIV across tight monolayer of polarized human endometrial cells. Cytokine.
	A more accurate assessment of HIV-1 replication dynamics and T-cell decay in vivo. Journal of Virology.
	Latent viral reservoir in a SIV-Macaca nemestrina model of HIV-1-infected patients on HAART. Journal of Virology.
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