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Vol. 3, No. 4, 28 February 2003
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Other Issues:
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AIDScience Perspectives:
Barebacking and bug chasers: expressions of an HIV subculture. Another wrinkle to the developing debate on the risks, consequences and value of an only partially effective future HIV vaccine.
By Marcia Trinfol.
[Free full text article] [About AIDScience articles] [See recent AIDScience articles]
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From Science:
Vaccine results lose significance under scrutiny. Few would have predicted the confusion that ensued when VaxGen released its long-awaited findings on 24 February. Over the next few days, VaxGen officials contradicted each other about how the data were analyzed and reported and whether some of the conclusions are statistically significant.
By Jon Cohen.
[Free full text article] [About AIDScience articles] [See recent AIDScience articles]
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Hot News:
From Medscape:
Unsurprising and surprising results of VaxGen's HIV vaccine trial. An expert interview with Mark Feinberg, medical director of the Hope Clinic at the Emory Vaccine Research Center in Atlanta, Georgia.
[Read paper] (one-time registration required)
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Expert panel does not believe unsafe injections spread HIV in Africa. An expert group hosted by WHO/UNAIDS has reaffirmed that unsafe sexual practices are responsible for the vast majority of HIV infections in sub-Saharan Africa, not unsafe medical injection practices.
[WHO/UNAIDS release]
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U.S. FDA approves Fuzeon. The first drug to block entry of HIV into immune cells provides new hope, but expected cost to be three times higher than most expensive current treatments.
[Trimeris press release] [Report]
[New England Journal of Medicine report]
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Satellite broadcast on HIV prevention. The U.S. CDC and the Public Health Training Network will present a satellite broadcast and web cast on rapid tests for HIV.
Morbidity and Mortality Weekly Report [More...]
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From Medscape:
Candidate HIV/AIDS vaccines: Lessons learned from the world's first phase III efficacy trials The North American/European trial will determined the efficacy of AIDSVAX B/B, a bivalent subtype B gp120 vaccine using MN and GNE8 antigens. The Thailand trial will determine the efficacy of AIDSVAX B/E, a bivalent gp120 vaccine containing the MN and A244 envelope antigens from subtype B and subtype E viruses respectively, against blood-borne infection.
AIDS 17(2), 147, 2003 [Read paper] (one-time registration required)
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Latest News Headlines:
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Could HIV help to save lives?. BBC News. February 28, 2003
| Ministry wants to counter V-1 Aids-cure publicity. Bangkok Post. February 28, 2003
| VaxGen issues statement on clinical trial data analysis. VaxGen release. February 28, 2003
| Private sector must do more to fight AIDS, business group says. Yahoo! News. February 28, 2003
| Malawi chief claims AIDS does not exist. Yahoo! News. February 28, 2003
| Survival of AIDS babies cause for joy, concern. Yahoo! News. February 28, 2003
| Seminal super shedders may cause disproportional number of new HIV infections. Medscape. February 27, 2003
| Africa devastated by AIDS. BBC News. February 27, 2003
| Grim global toll of AIDS. BBC News. February 27, 2003
| AIDS vaccine numbers off, statistician says — Effectiveness for minorities may be overstated. San Francisco Chronicle. February 27, 2003
| HIV vaccine testers wanted. BBC News. February 26, 2003
| Distrust may lead blacks to be wary of AIDS vaccine testing. Nando Times. February 26, 2003
| Stumbles on the AIDS front (editorial). New York Times. February 26, 2003
| Researchers plan tests on AIDS vaccine. South Florida Sun-Sentinel. February 26, 2003
| Many of China's docs, nurses may lack facts on HIV. Yahoo! News. February 26, 2003
| Activist groups say AIDS vaccine claims 'misleading'. Nando Times. February 26, 2003
| Initiative to unify control of HIV/AIDS and tuberculosis. Lancet Infectious Diseases. February 26, 2003
| Providing HIV/AIDS care in Mbarara, Uganda. Lancet Infectious Diseases. February 26, 2003
| VaxGen's stock reels on failure of AIDS drug. Los Angeles Times. February 25, 2003
| Official hopes to explain AIDS vaccine disparities. New York Times. February 25, 2003
| AIDS vaccine's failure may spur advance. New York Times. February 25, 2003
| Researchers doubt claim that AIDS drug protects minorities. Philadelphia Inquirer. February 25, 2003
| Firm vows to push for OK on AIDS vaccine. San Francisco Chronicle. February 25, 2003
| Scientists split over role of race in AIDS vaccine. San Francisco Chronicle. February 25, 2003
| Pressing On With AIDS Vaccine. Washington Post. February 25, 2003
| Evaluating interventions for HIV prevention in Africa. Lancet commentary. February 25, 2003
| Bad news and good news on AIDSVAX Phase III trials results. AIDScience. February 24, 2003
| Roche fuels HIV drugs debate. BBC News. February 24, 2003
| Media reaction on AIDSVAX Phase III trials results. AIDScience. February 24, 2003
| Fight AIDS the right way (editorial). Philadelphia Inquirer. February 23, 2003
| An HIV what-if (comment). Globe and Mail. February 23, 2003
| Stakes are high for VaxGen, AIDS vaccine. Los Angeles Times. February 22, 2003
| VaxGen to announce results of AIDSVAX B/B trial. VaxGen release. February 21, 2003
| AIDS ravages Swazi society. BBC News. February 21, 2003
| Dirty needles research rejected. BBC News. February 21, 2003
| Albania urged to act quickly to keep AIDS cases low. Yahoo! News. February 21, 2003
| Q&A: AIDS in Africa. BBC News. February 20, 2003
| Dirty needles 'spread Africa AIDS'. BBC News. February 20, 2003
| U.S. black market thrives on AIDS drug. Yahoo! News. February 20, 2003
| HIV drugs don't increase heart risk. Yahoo! News. February 20, 2003
| UCLA reopens probe of two researchers. Los Angeles Times. February 19, 2003
| Program on AIDS remains in doubt. Washington Times. February 19, 2003
| South Africa prisons face huge AIDS challenge — Study. Yahoo! News. February 19, 2003
| Prevention efforts ignore late-night crowd, study finds. CDC HIV/STD/TB Prevention News Update. February 19, 2003
| HIV researchers assess work. Newsday. February 18, 2003
| AIDS expert helps doctors learn from autopsies. New York Times. February 18, 2003
| New molecules promising for HIV microbicide. Yahoo! News. February 18, 2003
| VIRxSYS to initiate phase I clinical trials for innovative treatment of HIV/AIDS. VIRxSYS release. February 17, 2003
| Cuba leads the way in HIV fight. BBC News. February 17, 2003
| Tradition may lead to AIDS vaccine. Washington Post. February 15, 2003
| Cheaper, portable AIDS test emerges. Boston Globe. February 15, 2003
| AIDS data encouraging. Miami Herald. February 15, 2003
| Newly released ex-cons may help spread HIV. Yahoo! News. February 15, 2003
| Virus may block HIV's destructive power. New York Times. February 14, 2003
| A positive result for AIDS (Editorial). Lancet. February 14, 2003
| AIDS experts call for rethink of testing policy. Yahoo! News. February 14, 2003
| Anti-HIV cocktail drug for Indonesia. Bangkok Post. February 14, 2003
| AIDS program cleared by CDC. Los Angeles Times. February 14, 2003
| Glaxo AIDS drug beats standard treatment in study. Yahoo! News. February 14, 2003
| AIDS drug cocktails also increase heart attack risk, researchers say. Los Angeles Times. February 14, 2003
| Elizabeth Glaser Pediatric Aids Foundation announces $3 million in HIV/AIDS research grants. Boston.com. February 13, 2003
| Experiment shows AIDS vaccine unlikely to give total protection from disease. Yahoo! News. February 13, 2003
| Experimental AIDS vaccine safe for babies—U.S. study. Yahoo! News. February 13, 2003
| Drug-resistant HIV passed through breast milk. Yahoo! News. February 13, 2003
| AIDS vaccine seems elusive. Boston Globe. February 13, 2003
| Cavalier attitude blamed as HIV cases soar in South Florida. South Florida Sun-Sentinel. February 13, 2003
| Roche cuts AIDS drug price following protests. Yahoo! News. February 13, 2003
| Benefit of interrupting AIDS drugs is debated. Washington Post. February 13, 2003
| Many promising new AIDS drugs on the horizon. Boston.com. February 12, 2003
| AIDS, HIV up in U.S. for first time in decade. Yahoo! News. February 12, 2003
| Controversial AIDS film debuts at Berlin Film Fest. Yahoo! News. February 12, 2003
| Officials push use of a 20-minute HIV test. New York Times. February 12, 2003
| Monoclonal antibody decreases viral load in patients. Tanox release. February 12, 2003
| Internet chat rooms are common way to arrange risky sexual encounters. Yahoo! News. February 12, 2003
| U.S. criticizes South Africa AIDS stance. BBC News. February 12, 2003
| AIDS vaccine volunteers sought. Rocky Mountain News. February 12, 2003
| Bush criticized for not giving AIDS money to Global Fund. British Medical Journal news. February 11, 2003
| Ugandan AIDS vaccine trials begin on humans. Yahoo! News. February 11, 2003
| Progenics: New findings from a phase-2 clinical trial of PRO 542 HIV entry inhibitor. Business Wire. February 11, 2003
| New HIV barrier 'closer'. BBC News. February 10, 2003
| Media event held to push V1-Immunitor. Bangkok Post. February 9, 2003
| China — Need for safe sex education now urgent. San Francisco Chronicle. February 9, 2003
| AIDS in Asia — China becomes proactive. San Francisco Chronicle. February 9, 2003
| In Africa, free AIDS drugs and talk of life. New York Times. February 8, 2003
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Latest Journal Headlines:
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| Occupational exposure to HIV in health care settings. New England Journal of Medicine. (Posted: February 27, 2003) | | Genetic vaccination with the HIV-1 envelope genes linked to the gene encoding Flt-3 ligand. Journal of Immunology. (Posted: February 27, 2003) | | Prime boost vaccination strategies: CD8 T cell numbers, protection, and Th1 bias. Journal of Immunology. (Posted: February 27, 2003) | | NeuroAIDS: HIV-1 Tat-mediated apoptosis in human brain microvascular endothelial cells. Journal of Immunology. (Posted: February 27, 2003) | | NeuroAIDS: Up-regulation of proteinase-activated receptor 1 expression in astrocytes during HIV encephalitis. Journal of Immunology. (Posted: February 27, 2003) | | Pregnancy in perinatally HIV-infected adolescents and young adults — Puerto Rico, 2002. Morbidity and Mortality Weekly Report. (Posted: February 27, 2003) | | Turnover rates of B cells, T cells, and NK cells in SIV-infected and uninfected rhesus macaques. Journal of Immunology. (Posted: February 27, 2003) | | CD4+ T cells are required for secondary expansion and memory in CD8+ T lymphocytes. Nature. (Posted: February 27, 2003) | | Env induces virus expression from resting CD4+ T cells isolated from HIV-infected individuals. Journal of Immunology. (Posted: February 27, 2003) | | A region of the C-terminal tail of gp41 contains a neutralizing epitope. Journal of General Virology. (Posted: February 26, 2003) | | Virologic testing in the management of perinatal HIV exposure. The AIDS Reader. (Posted: February 26, 2003) | | Influence of human immunodeficiency virus type 1 subtype on mother-to-child transmission. Journal of General Virology. (Posted: February 26, 2003) | | Inability of natural killer cells to destroy autologous HIV-infected T lymphocytes. AIDS. (Posted: February 25, 2003) | | Mucosal and systemic HIV-1-specific immunity in HIV-1-exposed but uninfected heterosexual men. AIDS. (Posted: February 25, 2003) | | IFN-alpha restores HIV-induced alteration of NK cell perforin expression in vivo. AIDS. (Posted: February 25, 2003) | | Syndromic management of STIs and behaviour change interventions on transmission of HIV-1 in Uganda. Lancet. (Posted: February 25, 2003) | | Impact of SIV infection on lymphocyte numbers and T-cell turnover in different organs of monkeys. Blood. (Posted: February 21, 2003) | | Resistance to a retrovirus due to IFN gamma-dependent production of virus-neutralizing antibodies. Journal of Experimental Medicine. (Posted: February 21, 2003) | | Quantitative assessment of specific CD8+T cells in the mouse: application to vaccine research. Immunology Letters. (Posted: February 21, 2003) | | Syndecan captures, protects, and transmits HIV to T lymphocytes. Immunity. (Posted: February 21, 2003) | | IL-15 enhances survival and function of HIV-specific CD8(+) T cells. Blood. (Posted: February 21, 2003) | | Estimating cumulative probabilities from incomplete longitudinal binary responses. Statistics in Medicine. (Posted: February 21, 2003) | | The impact of migration on HIV-1 transmission in South Africa. Sexually Transmitted Diseases. (Posted: February 21, 2003) | | Prevalence of and risk factors in individuals testing for HIV at counseling centers in Brazil. Sexually Transmitted Diseases. (Posted: February 21, 2003) | | NeuroAIDS: Inhibition of long-term potentiation by interleukin-8: Implications for HIV-1-associated dementia. Journal of Neuroscience Research. (Posted: February 21, 2003) | | HIV and SIV-infected chimpanzees do not have increased intracellular levels of beta-chemokines. Journal of Medical Virology. (Posted: February 21, 2003) | | NeuroAIDS: Oxidative stress in HIV demented patients and protection ex vivo with novel antioxidants. Neurology. (Posted: February 21, 2003) | | Persons infected with HIV support routine health department contact for HIV partner notification. Journal of Acquired Immune Deficiency Syndromes. (Posted: February 19, 2003) | | Neutralization of HIV-1 by sCD4-17b, a single-chain chimeric protein. Journal of Virology. (Posted: February 19, 2003) | | SHIV89.6-induced protection against intravaginal challenge with pathogenic SIVmac239. Journal of Virology. (Posted: February 19, 2003) | | Induction of primary virus-cross-reactive HIV-1-neutralizing antibodies in small animals. Journal of Virology. (Posted: February 19, 2003) | | Tat-neutralizing antibodies in vaccinated macaques. Journal of Virology. (Posted: February 19, 2003) | | Rethinking the HIV counselling and testing model in the USA. Lancet. (Posted: February 19, 2003) | | Longitudinal analysis of HIV-1 RNA in breast milk. Journal of Infectious Diseases. (Posted: February 19, 2003) | | Breast-milk infectivity in human immunodefiency virus type 1-infected mothers. Journal of Infectious Diseases. (Posted: February 19, 2003) | | Review of medical encounters in the 5 years before a diagnosis: Implications for early detection. Journal of Acquired Immune Deficiency Syndromes. (Posted: February 19, 2003) | | Randomized, controlled evaluation of a prototype informed consent process for HIV vaccine trials. Journal of Acquired Immune Deficiency Syndromes. (Posted: February 19, 2003) | | Readiness for cessation of drug use among recent attenders and nonattenders of a NEP. Journal of Acquired Immune Deficiency Syndromes. (Posted: February 19, 2003) | | Diversity of HIV-1 env sequence after vertical transmission in mother-child pairs. Journal of Virology. (Posted: February 19, 2003) | | Abrogation of postentry restriction of HIV-1-based lentiviral vector transduction in simian cells. Proc. Natl. Acad. Sci. USA. (Posted: February 12, 2003) | | Replication, immunogenicity, and protective properties of SIVs expressing IL-4 or IFN. Virology. (Posted: February 12, 2003) | | Inhibition of Tat-mediated transactivation and HIV-1 replication by human anti-hCyclinT1 intrabodies. Journal of Biological Chemistry. (Posted: February 12, 2003) | | HIV-1 antiviral activity of recombinant natural killer cell enhancing factors, NKEF-A and NKEF-B. Journal of Biological Chemistry. (Posted: February 12, 2003) | | The potential public health and community impacts of safer injecting facilities. Journal of Acquired Immune Deficiency Syndromes. (Posted: February 12, 2003) | | Env-specific T-cell epitopic responses in HIV-1-uninfected immunized adults. Journal of Acquired Immune Deficiency Syndromes. (Posted: February 12, 2003) | | Gene expression and viral prodution in latently infected, resting CD4+ T cells. Proc. Natl. Acad. Sci. USA. (Posted: February 12, 2003) | | Surface-expressed HIV-1 Env induces the death of CD4 T cells through GP41. Virology. (Posted: February 12, 2003) | | Delayed application of condoms is a risk factor for HIV infection among homosexual and bisexual men. American Journal of Epidemiology. (Posted: February 11, 2003) | | CCR5 genotype and susceptibility to transmission of HIV-1 in women. Journal of Infectious Diseases. (Posted: February 10, 2003) | | A Semliki Forest virus-vectored experimental HIV clade A vaccine. Journal of General Virology. (Posted: February 10, 2003) | | Immunization with low doses of HIV-1 tat DNA delivered by novel cationic block copolymers. Vaccine. (Posted: February 10, 2003) | | Risk of prevalent HIV infection associated with incarceration among ID users in Bangkok. British Medical Journal. (Posted: February 10, 2003) | | HIV type 1 subtypes among bar and hotel workers in Moshi, Tanzania. AIDS Research and Human Retroviruses. (Posted: February 10, 2003) |
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