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Vol. 2, No. 21, 25 October 2002
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Other Issues:
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AIDScience Perspectives:
Vaccine research:
The possibility of HIV-positive patients becoming infected with a second, closely related strain despite having strong cellular immune responses controlling the first virus without drugs has set off alarms.
Superinfection: What does it mean for vaccines?
by Patricia Kahn, from the IAVI Report.
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Vaccine research:
Is the AIDS vaccine glass half full or half empty? With a host of animal studies on candidates that fail to protect against infection but delay or prevent disease, it can be difficult to tell—especially since it is not known whether results from animal studies are predictive of what will be seen in humans.
Barcelona sessions spark full discussion of partially effective vaccines
by Emily Bass, from the IAVI Report.
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Hot News:
A push-pull approach to maximize vaccine efficacy: Abrogating suppression with an IL-13 inhibitor while augmenting help with granulocyte/macrophage colony-stimulating factor and CD40L. CD4(+) helper cells have a role in CD8(+) cytotoxic T lymphocyte (CTL) induction by vaccines, but little is known about a counterbalancing role of CD4(+) T cells in down-modulating this response. Could abolishing this negative regulatory mechanism optimize vaccines?
Proc. Natl. Acad. Sci. USA 99(20), 13020, 1 October 2002 [Read abstract]
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Randomized trial of vitamin supplements in relation to transmission of HIV-1 through breastfeeding and early child mortality. Multivitamin (B, C, and E, but not A) supplementation of breastfeeding mothers reduced child mortality and HIV-1 transmission through breastfeeding among immunologically and nutritionally compromised women.
AIDS 16(14), 1935, 27 September 2002 [Read abstract]
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NeuroAIDS: HIV-1 infection and AIDS dementia are influenced by a mutant MCP-1 allele linked to increased monocyte infiltration of tissues and MCP-1 levels. Homozygosity for the monocyte chemoattractant protein-1 (MCP-1) -2578G allele was associated with a 50% reduction in the risk of acquiring HIV-1, but once HIV-1 infection was established, this same MCP-1 genotype was associated with accelerated disease progression and a 4.5-fold increased risk of HIV-associated dementia.
Proc. Natl. Acad. Sci. USA 99(21), 13795, 15 October 2002 [Read abstract]
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CD4 T cell depletion is linked directly to immune activation but only indirectly to the viral load. More data on the major determinant of CD4 decline, with potential implications for treatment.
The Journal of Immunology 169(6), 3400, 15 September 2002 [Read abstract]
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Latest News Headlines:
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Nearly one million Ugandans have died of AIDS-related illnesses since 1983. Yahoo! News. October 25, 2002
| New strategy proposed for fighting HIV. Yahoo! News. October 25, 2002
| AIDS vaccines for the world. IAVI. October 25, 2002
| Anticipating the news on AIDSVAX. AIDS Vaccine Advocacy Coalition. October 25, 2002
| Barriers to HIV testing—where next?. Lancet commentary. October 25, 2002
| Merck cuts cost of AIDS drug in poor countries. Financial Times. October 23, 2002
| Improve education to fight AIDS, says new report. Yahoo! News. October 22, 2002
| Hair sample may give clues to HIV drug response. Yahoo! News. October 22, 2002
| VaxGen's phase III trial in Thailand clears final scheduled safety review. VaxGen release. October 22, 2002
| White House hopes to make generic drugs available more quickly by blocking patent suits. San Francisco Chronicle. October 21, 2002
| World Bank commits $1 billion to fight Africa AIDS. Yahoo! News. October 21, 2002
| Inexpensive test predicts AIDS progression. Yahoo! News. October 21, 2002
| AIDS kills more in South Africa prisons. New York Times. October 21, 2002
| Forum to push for more AIDS funds. Newsday. October 19, 2002
| South Africa asks for more time on AIDS drugs policy. Yahoo! News. October 18, 2002
| Thai agency will begin producing AIDS drug. Yahoo! News. October 17, 2002
| U.S. AIDS group steps up action against Glaxo. Yahoo! News. October 17, 2002
| The Immune Response Corporation announces study. Immune Response Corporation release. October 17, 2002
| Official: Russia could soon have 3-4 million people infected with HIV. Yahoo! News. October 16, 2002
| Especially shunned, especially vulnerable. Boston Globe. October 16, 2002
| Glaxo faces amended suit over HIV drugs. Los Angeles Times. October 15, 2002
| HIV dementia risk causes new concern. Newsday. October 15, 2002
| Pharmaceutical giant to let generic company manufacture its AIDS drug. Yahoo! News. October 15, 2002
| Annan highlights China's AIDS problem. BBC News. October 14, 2002
| U.N.-backed AIDS fund gives approval to generic drugs. Financial Times. October 13, 2002
| FDA to review new AIDS drug Fuzeon. Newsday. October 13, 2002
| AIDS among the elderly. Miami Herald. October 13, 2002
| Cats could help find HIV vaccine. Nando Times. October 13, 2002
| Canada study probes pot use and HIV. Yahoo! News. October 13, 2002
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More news headlines: This week | Last week | Search archive |
Latest Journal Headlines:
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| Promising microbicide approach for prevention of HIV transmission needs more support. Pharmacotherapy. (Posted: October 25, 2002) | | Vitamin supplements in relation to transmission of HIV-1 through breastfeeding. AIDS. (Posted: October 25, 2002) | | A push-pull approach to maximize vaccine efficacy. Proc. Natl. Acad. Sci. USA. (Posted: October 25, 2002) | | Breastmilk erythropoietin and mother-to-child HIV transmission through breastmilk. Lancet. (Posted: October 25, 2002) | | Immunization of macaques with live SHIV vaccines conferred protection against AIDS. Virology. (Posted: October 25, 2002) | | A SIV nef peptide is a dominant cytotoxic T lymphocyte epitope. Virology. (Posted: October 25, 2002) | | Lymphoid activation: a confounding factor in AIDS vaccine development?. Journal of General Virology. (Posted: October 25, 2002) | | In vivo priming of HIV-specific CTLs determines selective cross-reactive immune responses. Journal of Immunology. (Posted: October 25, 2002) | | HIV-1 Tat-based vaccines: From basic science to clinical trials. DNA and Cell Biology. (Posted: October 25, 2002) | | Targeting Tat and IFN alpha as a therapeutic AIDS vaccine. DNA and Cell Biology. (Posted: October 25, 2002) | | Design and in vivo immunogenicity of a polyvalent vaccine based on SIVmac regulatory genes. DNA and Cell Biology. (Posted: October 25, 2002) | | Tat and Rev-targeted immunization as a preventive vaccine against mucosal challenge with SHIV-BX08. DNA and Cell Biology. (Posted: October 25, 2002) | | Immunogenicity of HIV-1IIIB and SHIV 89.6P Tat and Tat toxoids in rhesus macaques. DNA and Cell Biology. (Posted: October 25, 2002) | | NeuroAIDS: HIV-1 infection and AIDS dementia are influenced by a mutant MCP-1 allele. Proc. Natl. Acad. Sci. USA. (Posted: October 24, 2002) | | Characterization of sexually transmitted disease clinic patients with recent HIV infection. The Journal of Infectious Diseases. (Posted: October 22, 2002) | | Mucosal immunization with inactivated HIV virus plus CpG oligodeoxynucleotides. The Journal of Infectious Diseases. (Posted: October 21, 2002) | | Preparation of clinical-grade recombinant canarypox HIV vaccine loaded human dendritic cells. The Journal of Infectious Diseases. (Posted: October 21, 2002) | | Heat-denatured HIV-1 protein 24 antigen: Prognostic value in adults with early-stage disease. The Journal of Infectious Diseases. (Posted: October 21, 2002) | | Prime-boost immunization with DNA and modified vaccinia virus ankara vectors. The Journal of Infectious Diseases. (Posted: October 21, 2002) | | NeuroAIDS: Glucocorticoid exacerbation of gp120 neurotoxicity: Role of microglia. Experimental Neurology. (Posted: October 18, 2002) | | Role for human immunodeficiency virus type 1 membrane cholesterol in viral internalization. Journal of Virology. (Posted: October 18, 2002) | | Effects of CTLs directed against a single SIV Gag CTL epitope on the course of SIVmac239 infection. Journal of Virology. (Posted: October 18, 2002) | | Diversity of receptors binding HIV on dendritic cell subsets. Nature Immunology. (Posted: October 18, 2002) | | Impact of antigen expression kinetics on the effectiveness of HIV-specific cytotoxic T lymphocytes. European Journal of Immunology. (Posted: October 18, 2002) | | Slowly declining levels of viral RNA and DNA in vaccinated macaques. Journal of Virology. (Posted: October 18, 2002) | | Magnitude and frequency of CTL responses: identification of immunodominant regions. Journal of Virology. (Posted: October 18, 2002) | | Are HIV care providers talking with patients about safer sex and disclosure?. AIDS. (Posted: October 15, 2002) |
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