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AIDScience Prevention Perspective:
With fears fading, more gays spurn old preventive message
By Erica Goode
Public health experts are facing a new and perplexing challenge: prevention workers find themselves desperately preaching to a choir they thought was long ago converted. In many cases, the prevention slogans that galvanized gay men in the early years of the epidemic now fall on deaf ears. Surveys of gay men in San Francisco and in other cities indicate that an increasing number, young and old, HIV negative and HIV positive, are engaging in high-risk sexual behavior.
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Science Classic Papers:
Selective transcription and modulation of resting T cell activity by preintegrated HIV DNA
Yuntao Wu and Jon W. Marsh, Science 293(5534):1503-1506, 24 August 2001.
A new unexpected step in the process that HIV uses to infect human cells has been discovered. Most CD4+ T cells, in which HIV replicates predominantly, exist in a resting state that resists HIV infection. But in a new Science article researchers at the U.S. National Institute of Mental Health show that after reverse transcription of its RNA and before the integration of the viral DNA into the cellular DNA, the HIV DNA serves as a template to make the viral proteins Nef and Tat. This preintegration transcription in quiescent cells leads to increased T cell activation and viral replication.
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Hot News:
International Meeting of the Institute of Human Virology — September 9-13, 2001
Researchers from around the world are in Baltimore this week to participate in the 2001 International Meeting of the Institute of Human Virology (the "Gallo meeting"). The meeting, which focuses on HIV/AIDS and a range of cancers, includes more than 200 presentations from local and international experts about the most promising vaccines, therapies, and current research.
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